Article
Development and validation of a multiplex real-time PCR assay for simultaneous genotyping and human T-lymphotropic virus type 1, 2, and 3 proviral load determination.
Journal of clinical microbiology - 1 Nov 2009
Moens Britta, López Giovanni, Adaui Vanessa, González Elsa, Kerremans Lien, Clark Daniel, Verdonck Kristien, Gotuzzo Eduardo, Vanham Guido, Cassar Olivier, Gessain Antoine, Vandamme Anne-Mieke, Van Dooren Sonia
Abstract excerpt
The human T-lymphotropic virus (HTLV) proviral load remains the best surrogate marker for disease progression. Real-time PCR techniques have been developed for detection and quantification of cosmopolitan HTLV type 1a (HTLV-1a) and HTLV-2. Since a growing level of diversity in subtypes and genotypes is observed, we developed a multiplex quantitative PCR for simultaneous detection, genotyping, and quantification...
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