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The Roles of Chemokines in Rabies Virus Infection: Overexpression May Not Always Be Beneficial

10 Sept 2009

Abstract excerpt

It was found previously that induction of innate immunity, particularly chemokines, is an important mechanism of rabies virus (RABV) attenuation. To evaluate the effect of overexpression of chemokines on RABV infection, chemokines macrophage inflammatory protein 1alpha (MIP-1alpha), RANTES, and IP-10 were individually cloned into the genome of attenuated RABV strain HEP-Flury. These recombinant RABVs were...

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PMID: 19740983
DOI: 10.1128/jvi.01346-09

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