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Article

Lyssavirus infection activates interferon gene expression in the brain

7 Aug 2006

Abstract excerpt

To investigate the innate immune response within the brain to lyssavirus infection, key transcripts indicative of innate defences were measured in a mouse model system. Following infection with Rabies virus, transcript levels for type 1 interferons (IFN-alpha and -beta), the inflammatory mediator interleukin 6 (IL-6) and the antiviral protein Mx1 increased in the brains of mice. Intracranial inoculation resulted...

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PMID: 16894206
DOI: 10.1099/vir.0.82024-0

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