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Article

Reinvestigation of the role of the rabies virus glycoprotein in viral pathogenesis using a reverse genetics approach.

Journal of neurovirology - 1 Oct 2000

Morimoto K, Foley H D, McGettigan J P, Schnell M J, Dietzschold B

Abstract excerpt

The rabies virus glycoprotein (G) gene of the highly neuroinvasive and neurotropic strains SHBRV-18, CVS-N2c, and CVS-B2c was introduced into the non-neuroinvasive and less neurotropic SN-10 strain to provide further insight into the role of G in the pathogenesis of rabies. Phenotypic analyses of the recombinant viruses revealed, as expected, that the neurotropism of a particular rabies virus strain was a...

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Identifiers

PMID: 11031690
DOI: 10.3109/13550280009018301

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