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Role of Interferon Antagonist Activity of Rabies Virus Phosphoprotein in Viral Pathogenicity

29 Apr 2010

Abstract excerpt

The fixed rabies virus (RV) strain Nishigahara kills adult mice after intracerebral inoculation, whereas the chicken embryo fibroblast cell-adapted strain Ni-CE causes nonlethal infection in adult mice. We previously reported that the chimeric CE(NiP) strain, which has the phosphoprotein (P protein) gene from the Nishigahara strain in the genetic background of the Ni-CE strain, causes lethal infection in adult...

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PMID: 20427527
DOI: 10.1128/jvi.00011-10

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