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Article

Structure and sequence variation of the canine perforin gene.

Veterinary immunology and immunopathology - 15 Feb 2010

Neta M, Wen X, Moore P F, Bienzle D

Abstract excerpt

Lymphocyte-mediated cytotoxicity is essential to control viral infections, limit lymphocyte expansion and activation, and survey for malignant cells. Humans with defects in lymphocyte cytotoxicity have reduced perforin function resulting in uncontrolled lymphocyte expansion, leading to excessive histiocyte activation and a hemophagocytic disorder. Dog breeds such as Bernese mountain dogs (BMD) have a high...

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PMID: 19740553
DOI: 10.1016/j.vetimm.2009.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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