Article
Identification of a Hypomorphic FANCG Variant in Bernese Mountain Dogs.
Genes - 21 Sept 2022
Meek Katheryn, Yang Ya-Ting, Takada Marilia, Parys Maciej, Richter Marlee, Engleberg Alexander I, Thaiwong Tuddow, Griffin Rachel L, Schall Peter Z, Kramer Alana J, Yuzbasiyan-Gurkan Vilma
Abstract excerpt
Bernese mountain dogs (BMDs), have an overall cancer incidence of 50%, half of which is comprised of an otherwise rare tumor, histiocytic sarcoma (HS). While recent studies have identified driver mutations in the MAPK pathway, identification of key predisposing genes has been elusive. Studies have identified several loci to be associated with predisposition to HS in BMDs, including near the MTAP/CDKN2A region,...
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