Article
Characterization of antimicrobial activity against Listeria and cytotoxicity of native melittin and its mutant variants.
Colloids and surfaces. B, Biointerfaces - 1 Jul 2016
Wu Xi, Singh Atul K, Wu Xiaoyu, Lyu Yuan, Bhunia Arun K, Narsimhan Ganesan
Abstract excerpt
Antimicrobial peptides (AMPs) are relatively short peptides that have the ability to penetrate the cell membrane, form pores leading to cell death. This study compares both antimicrobial activity and cytotoxicity of native melittin and its two mutants, namely, melittin I17K (GIGAVLKVLTTGLPALKSWIKRKRQQ) with a higher charge and lower hydrophobicity and mutant G1I (IIGAVLKVLTTGLPALISWIKRKRQQ) of higher...
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