Article
N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins.
FEBS letters - 21 Jul 2009
Polyansky Anton A, Vassilevski Alexander A, Volynsky Pavel E, Vorontsova Olga V, Samsonova Olga V, Egorova Natalya S, Krylov Nicolay A, Feofanov Alexei V, Arseniev Alexander S, Grishin Eugene V, Efremov Roman G
Abstract excerpt
In silico structural analyses of sets of alpha-helical antimicrobial peptides (AMPs) are performed. Differences between hemolytic and non-hemolytic AMPs are revealed in organization of their N-terminal region. A parameter related to hydrophobicity of the N-terminal part is proposed as a measure of the peptide propensity to exhibit hemolytic and other unwanted cytotoxic activities. Based on the information...
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