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Single nucleotide polymorphisms of 17beta-hydroxysteroid dehydrogenase type 7 gene: mechanism of estramustine-related adverse reactions?

International journal of urology : official journal of the Japanese Urological Association - 1 Oct 2009

Ozeki Takeshi, Takeuchi Megumi, Suzuki Motofumi, Kitamura Tadaichi, Takayanagi Risa, Yokoyama Haruko, Yamada Yasuhiko

Abstract excerpt

OBJECTIVES: To investigate the influence of single nucleotide polymorphisms (SNP) on transcription of the 17beta-hydroxysteroid dehydrogenase (HSD17B7) gene. METHODS: Luciferase reporter genes containing a 5'-flanking of the HSD17B7 gene, as well as the sequence around the SNP, were transfected into LNCaP and DU145 cells. Then, luciferase assays were carried out. RESULTS: The presence of the G allele resulted in...

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PMID: 19735314
DOI: 10.1111/j.1442-2042.2009.02374.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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