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Article

Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2010

Carcereny Enric, Ramirez Jose Luis, Sanchez-Ronco Maria, Isla Dolores, Cobo Manuel, Moran Teresa, de Aguirre Itziar, Okamoto Tatsuro, Wei Jia, Provencio Mariano, Lopez-Vivanco Guillermo, Camps Carlos, Domine Manuel, Alberola Vicente, Sanchez Jose Miguel, Massuti Bartomeu, Mendez Pedro, Taron Miquel, Rosell Rafael

Abstract excerpt

Nicotine acetylcholine receptors (nAChRs) are associated with resistance to gemcitabine, cisplatin and paclitaxel in non-small-cell lung cancer (NSCLC) cell lines. Three single nucleotide polymorphisms (SNPs) of CHRNA3, CHRNA5 and LOC123688 increase lung cancer risk. These SNPs may have influenced outcome in patients treated in our phase III trial. Stage IV NSCLC patients were treated with customized chemotherapy...

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Source

Identifiers

PMID: 19733931
DOI: 10.1016/j.lungcan.2009.08.004

Genes

CHRNA3
ERCC1
CHRNA5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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