Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon.

doi:10.1016/j.humpath.2009.06.002

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Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon.

Human pathology - 1 Jan 2010

Hiraoka Sakiko, Kato Jun, Horii Joichiro, Saito Shunsuke, Harada Keita, Fujita Hideyuki, Kuriyama Motoaki, Takemoto Koji, Uraoka Toshio, Yamamoto Kazuhide

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The aim of this study is to evaluate the methylation status of normal colonic mucosa in relation to the stage of neoplasia arising from the mucosa. The methylation status of 2 age-related loci (ESR1 and MYOD1) and global methylation (the mean of Alu and Sat2) in the normal colonic mucosa of 156 patients with and without colorectal neoplasia were examined. The distal colon and proximal colon were analyzed...

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Methylation status of normal background mucosa is correlated with occurrence and development of neoplasia in the distal colon.

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