Article
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Cancer science - 1 Jun 2009
Horii Joichiro, Hiraoka Sakiko, Kato Jun, Saito Shunsuke, Harada Keita, Fujita Hideyuki, Kaji Eisuke, Yamamoto Kazuhide
Abstract excerpt
The promoter region of estrogen receptor 1 (ESR1) has been shown to be methylated in normal colorectal mucosa in an age-dependent manner. However, the methylation of this region in colorectal tumors has not sufficiently been investigated. The methylation status of ESR1 in 105 colorectal adenoma tissues was examined by MethyLight and presented as the percentage of methylated references (PMR). Factors that affect...
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