Mechanistic analysis of RNA synthesis by RNA-dependent RNA polymerase from two promoters reveals similarities to DNA-dependent RNA polymerase.

Article

Mechanistic analysis of RNA synthesis by RNA-dependent RNA polymerase from two promoters reveals similarities to DNA-dependent RNA polymerase.

RNA (New York, N.Y.) - 1 Apr 1998

Adkins S, Stawicki S S, Faurote G, Siegel R W, Kao C C

Abstract excerpt

The brome mosaic virus (BMV) RNA-dependent RNA polymerase (RdRp) directs template-specific synthesis of (-)-strand genomic and (+)-strand subgenomic RNAs in vitro. Although the requirements for (-)-strand RNA synthesis have been characterized previously, the mechanism of subgenomic RNA synthesis...

Topics

Alphavirus
Base Sequence
Bromovirus
Conserved Sequence
DNA-Directed RNA Polymerases
Mutation
Promoter Regions, Genetic
RNA, Viral
RNA-Dependent RNA Polymerase
Virus Replication

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