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Article

The long-lasting enigma of polycytidine (polyC) tract

4 Aug 2021

Abstract excerpt

Long polycytidine (polyC) tracts varying in length from 50 to 400 nucleotides were first described in the 5'-noncoding region (NCR) of genomes of picornaviruses belonging to the Cardio- and Aphthovirus genera over 50 years ago, but the molecular basis of their function is still unknown. Truncation or complete deletion of the polyC tracts in picornaviruses compromises virulence and pathogenicity but do not affect...

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PMID: 34347852
DOI: 10.1371/journal.ppat.1009739

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