Article
The genotype-phenotype relationship in multicellular pattern-generating models--the neglected role of pattern descriptors.
BMC systems biology - 4 Sept 2009
Martens Harald, Veflingstad Siren R, Plahte Erik, Martens Magni, Bertrand Dominique, Omholt Stig W
Abstract excerpt
BACKGROUND: A deep understanding of what causes the phenotypic variation arising from biological patterning processes, cannot be claimed before we are able to recreate this variation by mathematical models capable of generating genotype-phenotype maps in a causally cohesive way. However, the concept of pattern in a multicellular context implies that what matters is not the state of every single cell, but certain...
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