Article
Using expression and genotype to predict drug response in yeast.
PloS one - 4 Sept 2009
Ruderfer Douglas M, Roberts David C, Schreiber Stuart L, Perlstein Ethan O, Kruglyak Leonid
Abstract excerpt
Personalized, or genomic, medicine entails tailoring pharmacological therapies according to individual genetic variation at genomic loci encoding proteins in drug-response pathways. It has been previously shown that steady-state mRNA expression can be used to predict the drug response (i.e., sens...
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