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Article

Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk.

Scientific reports - 10 Mar 2015

Figlioli Gisella, Chen Bowang, Elisei Rossella, Romei Cristina, Campo Chiara, Cipollini Monica, Cristaudo Alfonso, Bambi Franco, Paolicchi Elisa, Hoffmann Per, Herms Stefan, Kalemba Michał, Kula Dorota, Pastor Susana, Marcos Ricard, Velázquez Antonia, Jarząb Barbara, Landi Stefano, Hemminki Kari, Gemignani Federica, Försti Asta

Abstract excerpt

A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications on low-incidence cohorts suggested a strong association of differentiated thyroid cancer (DTC) with single nucleotide polymorphisms (SNPs) at 9q22.33, 2q35, 20q11.22-q12 and 14q24.3. Moreover, six additional susceptibility loci were associated with the disease only among Italians. The present study had...

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Identifiers

PMID: 25753578
DOI: 10.1038/srep08922
PMCID: PMC4354074

Genes

FOXA2

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