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Article

Phenolyzer: phenotype-based prioritization of candidate genes for human diseases.

Nature methods - 1 Sept 2015

Yang Hui, Robinson Peter N, Wang Kai

Abstract excerpt

Prior biological knowledge and phenotype information may help to identify disease genes from human whole-genome and whole-exome sequencing studies. We developed Phenolyzer (http://phenolyzer.usc.edu), a tool that uses prior information to implicate genes involved in diseases. Phenolyzer exhibits superior performance over competing methods for prioritizing Mendelian and complex disease genes, based on disease or...

Topics

Algorithms
Base Sequence
Chromosome Mapping
Data Mining
Databases, Genetic
Exome
Genetic Diseases, Inborn
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Phenotype

Sequence Analysis, DNA

Software

Source

Open in PubMed Open full text

Identifiers

PMID: 26192085
DOI: 10.1038/nmeth.3484
PMCID: PMC4718403

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