Article
Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV.
Immunology letters - 1 Mar 1999
Evans D T, Knapp L A, Jing P, Mitchen J L, Dykhuizen M, Montefiori D C, Pauza C D, Watkins D I
Abstract excerpt
Highly polymorphic HLA class I molecules may influence rates of disease progression of HIV-infected individuals. Recent evidence suggests that individuals who mount vigorous CTL responses to multiple HIV-1 epitopes have reduced viral loads, and survive longer than individuals that make a less robust or less diverse CTL response. It has been difficult, however, to define associations between particular HLA class I...
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