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Article

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification

2 Sept 2009

Abstract excerpt

BACKGROUND: Chondrogenesis and subsequent endochondral ossification are processes tightly regulated by the transcription factor Sox9 (SRY-related high mobility group-Box gene 9), but molecular mechanisms underlying this activity remain unclear. Here we report that coactivator-associated arginine methyltransferase 1 (CARM1) regulates chondrocyte proliferation via arginine methylation of Sox9. RESULTS: CARM1-null...

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PMID: 19725955
DOI: 10.1186/1471-213x-9-47

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