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Article

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma

29 Aug 2009

Abstract excerpt

Because melanomas are intrinsically resistant to conventional radiotherapy and chemotherapy, many alternative treatment approaches have been developed such as biochemotherapy and immunotherapy. The most common cause of multidrug resistance (MDR) in human cancers is the expression and function of one or more ATP-binding cassette (ABC) transporters that efflux anticancer drugs from cells. Melanoma cells express a...

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PMID: 19725928
DOI: 10.1111/j.1755-148x.2009.00630.x

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