Principal expression of two mRNA isoforms (<i>ABCB  5α</i> and <i>ABCB  5β</i> ) of the ATP‐binding cassette transporter gene <i>ABCB</i> 5 in melanoma cells and melanocytes

Abstract excerpt

ATP-binding cassette (ABC) transporters play a pivotal role in physiology and pathology. We identified and cloned two novel mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ABC transporter ABCB 5 in human melanoma cells. The deduced ABCB 5alpha protein appears to be an altered splice variant containing only a putative ABC, whereas the ABCB 5beta isoform shares approximately 70% similarity with ABCB1 (MDR1) and...

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