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C-terminal end and aminoacid Lys48 in HMG-CoA lyase are involved in substrate binding and enzyme activity.

Molecular genetics and metabolism - 1 Jun 2007

Carrasco Patricia, Menao Sebastian, López-Viñas Eduardo, Santpere Gabriel, Clotet Josep, Sierra Adriana Y, Gratacós Esther, Puisac Beatriz, Gómez-Puertas Paulino, Hegardt Fausto G, Pie Juan, Casals Núria

Abstract excerpt

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) lyase adopts a (betaalpha)(8) TIM barrel structure with an additional beta9, alpha11 and alpha12 helices. Location of HMG part of the substrate has been suggested but the binding mode for the CoA moiety remains to be resolved. As mutation F305 fs(-2), whic...

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PMID: 17459752
DOI: 10.1016/j.ymgme.2007.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17459752-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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