Article
Linked marker haplotypes and the delta F508 mutation in adults with mild pulmonary disease and cystic fibrosis.
Lancet (London, England) - 16 Jun 1990
Santis G, Osborne L, Knight R A, Hodson M E
Abstract excerpt
The frequencies of the delta F508 mutation and haplotypes at the loci linked to the cystic fibrosis (CF) gene have been compared in adult CF patients with very mild and with severe lung disease. In patients who are compound heterozygotes for the delta F508 mutation, or who lack the mutation on both chromosomes, the as yet undefined mutations may influence the severity of lung involvement. In patients homozygous...
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