Severity of cystic fibrosis in patients homozygous and heterozygous for delta F508 mutation.

doi:10.1016/0140-6736(91)92449-c

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Article

Severity of cystic fibrosis in patients homozygous and heterozygous for delta F508 mutation.

Lancet (London, England) - 16 Mar 1991

Johansen H K, Nir M, Høiby N, Koch C, Schwartz M

Abstract excerpt

To assess the relation between genotype and severity of disease in cystic fibrosis (CF) the frequencies and extent of several features of its phenotypic expression were investigated in the 235 patients who attend the Danish CF Centre. 14 patients who attend irregularly and 3 who do not carry the delta F508 mutation at all were excluded. The case-reports of the remaining 218 patients (aged 4 months to 41 years)...

Topics

Adolescent
Adult
Age Factors
Blood Proteins
Calgranulin A
Child
Child, Preschool
Chronic Disease
Cystic Fibrosis
Denmark
Evaluation Studies as Topic
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Forced Expiratory Volume

Heterozygote

Homozygote

Humans

Incidence

Infant

Source

Open in PubMed

Identifiers

PMID: 1671990
DOI: 10.1016/0140-6736(91)92449-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1671990-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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