Frequency of the delta F508 mutation and XV2c,KM19 haplotypes in cystic fibrosis families from The Netherlands: haplotypes without delta F508 still in disequilibrium.

Abstract excerpt

We have determined the frequency of the major cystic fibrosis (CF) three base pair deletion (delta F508) mutation in 152 CF chromosomes from patients originating from the northern part of The Netherlands. In these patients, the deletion represents approximately 76% of CF mutations. Meconium ileus...

Topics

• Cystic Fibrosis
• Gene Frequency
• Haplotypes
• Humans
• Infant, Newborn
• Meconium Aspiration Syndrome
• Mutation
• Netherlands