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Article

Roles of Progranulin in Sexual Differentiation of the Developing Brain and Adult Neurogenesis

1 Jan 2009

Abstract excerpt

Progranulin (PGRN) is a growth modulating factor released by a variety of cells. This molecule has gained the attention of the neuroscience community with recent discoveries of multifunctional roles of PGRN in normal brain and neurodegenerative disorders. We focus on novel roles of PGRN as a sex steroid-responsible gene in the developing and adult rodent brain. While the developing brain is feminine by default,...

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PMID: 19721334
DOI: 10.1262/jrd.20249

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