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Article

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2009

Järvinen Heikki J, Renkonen-Sinisalo Laura, Aktán-Collán Katja, Peltomäki Päivi, Aaltonen Lauri A, Mecklin Jukka-Pekka

Abstract excerpt

PURPOSE: Colonoscopies with polypectomies and endometrial biopsies with transvaginal ultrasonography, repeated at 2- to 3-year intervals, are performed for prevention or early detection of cancer in patients with DNA mismatch repair gene mutation causing Lynch syndrome. The long-term effectivenes...

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Source

Identifiers

PMID: 19720893
DOI: 10.1200/JCO.2009.23.7784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19720893-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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