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Article

Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer.

Gastroenterology - 1 May 2000

Järvinen H J, Aarnio M, Mustonen H, Aktan-Collan K, Aaltonen L A, Peltomäki P, De La Chapelle A, Mecklin J P

Abstract excerpt

BACKGROUND & AIMS: Identification of the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome enables prevention of colorectal cancer (CRC) by means of colonoscopy and polypectomies. We evaluated the efficacy of screening in a controlled trial over 15 years. METHODS: Incidence of CRC and survival were compared in 2 cohorts of at-risk members of 22 families with HNPCC. Colonic screening at 3-year intervals...

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Identifiers

PMID: 10784581
DOI: 10.1016/s0016-5085(00)70168-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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