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Article

The induction of APC with a distinct tolerogenic phenotype via contact-dependent STAT3 activation.

PloS one - 31 Aug 2009

Gur-Wahnon Devorah, Borovsky Zipora, Liebergall Meir, Rachmilewitz Jacob

Abstract excerpt

BACKGROUND: Activation of the signal transducer and activator of transcription 3 (STAT3) within antigen presenting cells (APCs) is linked to abnormal APCs differentiation and function. We have previously shown that STAT3 is activated within APC by a novel contact-dependent mechanism, which plays a key role in mediating the immunomodulatory effects of hMSC. In order to better understand the underlying mechanisms...

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Source

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Identifiers

PMID: 19718269
DOI: 10.1371/journal.pone.0006846
PMCID: PMC2731174

Genes

STAT3
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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