Article
Transfer of Cellular Content from the Allogeneic Cell-Based Cancer Vaccine DCP-001 to Host Dendritic Cells Hinges on Phosphatidylserine and Is Enhanced by CD47 Blockade.
Cells - 19 Nov 2021
Zuo Haoxiao, van Lierop Marie-José C, Kaspers Jorn, Bos Remco, Reurs Anneke, Sarkar Saheli, Konry Tania, Kamermans Alwin, Kooij Gijs, de Vries Helga E, de Gruijl Tanja D, Karlsson-Parra Alex, Manting Erik H, Kruisbeek Ada M, Singh Satwinder Kaur
Abstract excerpt
DCP-001 is a cell-based cancer vaccine generated by differentiation and maturation of cells from the human DCOne myeloid leukemic cell line. This results in a vaccine comprising a broad array of endogenous tumor antigens combined with a mature dendritic cell (mDC) costimulatory profile, functioning as a local inflammatory adjuvant when injected into an allogeneic recipient. Intradermal DCP-001 vaccination has...
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