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MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

27 Aug 2009

Abstract excerpt

BACKGROUND: MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. Transcription of the three miRNA miR-34 family members was recently found to be directly regulated by p53. Among the target proteins regulated by miR-34 are Notch pathway proteins and Bcl-2, suggesting the...

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PMID: 19714243
DOI: 10.1371/journal.pone.0006816

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