Article
Polymorphism of DRw52 and its association with DRw11 and DRw12 in South African blacks (Negroes) and individuals of mixed ancestry (Cape coloreds).
Human immunology - 1 May 1990
Martell R W, Oudshoorn M, Arendse B, du Toit E D
Abstract excerpt
The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 haplotypes were associated with a TaqI restriction fragment length polymorphism which has not been...
Topics
- Alleles
- Black People
- Blotting, Southern
- DNA
- Electrophoresis, Polyacrylamide Gel
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Haplotypes
- Humans
- Polymorphism, Genetic