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Article

Variation in the size of human apolipoprotein(a) is due to a hypervariable region in the gene.

Human genetics - 1 May 1990

Lindahl G, Gersdorf E, Menzel H J, Seed M, Humphries S, Utermann G

Abstract excerpt

We have investigated whether the size heterogeneity of the human apolipoprotein(a) [apo(a)] is due to differences in the number of plasminogen kringle 4-like repeat units present in the different alleles. Using the Southern blot hybridization technique and a DNA probe for the kringle 4 domain of plasminogen, we have observed that in 31 different individuals a 5.8-kb PvuII restriction fragment band varies widely...

Topics

Alleles
Apolipoproteins A
Base Sequence
Blotting, Southern
DNA Probes
Female
Genes
Humans
Male
Molecular Sequence Data
Pedigree
Peptide Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasminogen

Polymorphism, Restriction Fragment Length

Regression Analysis

Repetitive Sequences, Nucleic Acid

Source

Identifiers

PMID: 1970974
DOI: 10.1007/BF00210810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1970974-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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