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Article

The Double-Edged Sword of Autophagy Modulation in Cancer

26 Aug 2009

Abstract excerpt

Macroautophagy (autophagy) is a lysosomal degradation pathway for the breakdown of intracellular proteins and organelles. Although constitutive autophagy is a homeostatic mechanism for intracellular recycling and metabolic regulation, autophagy is also stress responsive, in which it is important for the removal of damaged proteins and organelles. Autophagy thereby confers stress tolerance, limits damage, and...

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PMID: 19706824
DOI: 10.1158/1078-0432.ccr-07-5023

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