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Autophagy, Metabolism, and Cancer

12 Nov 2015

Abstract excerpt

Macroautophagy (autophagy hereafter) captures intracellular proteins and organelles and degrades them in lysosomes. The degradation breakdown products are released from lysosomes and recycled into metabolic and biosynthetic pathways. Basal autophagy provides protein and organelle quality control by eliminating damaged cellular components. Starvation-induced autophagy recycles intracellular components into...

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PMID: 26567363
DOI: 10.1158/1078-0432.ccr-15-0490

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