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Crystal Structure of Porcine Reproductive and Respiratory Syndrome Virus Leader Protease Nsp1α

18 Aug 2009

Abstract excerpt

Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV), a positive-strand RNA virus that belongs to the Arteriviridae family of Nidovirales, has been identified as the causative agent of PRRS. Nsp1alpha is the amino (N)-terminal protein in a polyprotein encoded by the PRRSV genome and is reported to be crucial for subgenomic mRNA synthesis, presumably by serving as a transcription factor. Before...

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PMID: 19706710
DOI: 10.1128/jvi.02579-08

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