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Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells

16 Jun 2009

Abstract excerpt

Human polyomavirus, JCV, causes fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). It has been shown that 5HT(2A)R acts as a cellular receptor for JCV on human glial cells. In the current study, we examined the inhibitory effects of 5HT(2A)R antagonists, ketanserin and ritanserin, both on JCV infection and on propagation by using human neuroblastoma cells IMR-32 and JCI, which...

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PMID: 19703243
DOI: 10.1111/j.1348-0421.2009.00156.x

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