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Article

Toward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.

Chemical biology & drug design - 1 Sept 2009

Kairys Visvaldas, Gilson Michael K, Lather Viney, Schiffer Celia A, Fernandes Miguel X

Abstract excerpt

Previous studies have shown the usefulness of the substrate envelope concept in the analysis and prediction of drug resistance profiles for human immunodeficiency virus protease mutants. This study tests its applicability to several other therapeutic targets: Abl kinase, chitinase, thymidylate synthase, dihydrofolate reductase, and neuraminidase. For the targets where many (> or =6) mutation data are available to...

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Source

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Identifiers

PMID: 19703025
DOI: 10.1111/j.1747-0285.2009.00851.x
PMCID: PMC2860775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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