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Article

Dynamics of preferential substrate recognition in HIV-1 protease: redefining the substrate envelope.

Journal of molecular biology - 22 Jul 2011

Ozen Ayşegül, Haliloğlu Türkan, Schiffer Celia A

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) protease (PR) permits viral maturation by processing the gag and gag-pro-pol polyproteins. HIV-1 PR inhibitors (PIs) are used in combination antiviral therapy but the emergence of drug resistance has limited their efficacy. The rapid evolution of HIV-1 necessitates consideration of drug resistance in novel drug design. Drug-resistant HIV-1 PR variants no longer...

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Conserved Sequence
Crystallography, X-Ray
Drug Resistance, Viral
HIV-1
HIV Protease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hydrogen Bonding

Molecular Dynamics Simulation

Substrate Specificity

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Identifiers

PMID: 21762811
DOI: 10.1016/j.jmb.2011.03.053
PMCID: PMC3139114

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