Article
Design of mutation-resistant HIV protease inhibitors with the substrate envelope hypothesis.
Chemical biology & drug design - 1 May 2007
Chellappan Sripriya, Kiran Kumar Reddy G S, Ali Akbar, Nalam Madhavi N L, Anjum Saima Ghafoor, Cao Hong, Kairys Visvaldas, Fernandes Miguel X, Altman Michael D, Tidor Bruce, Rana Tariq M, Schiffer Celia A, Gilson Michael K
Abstract excerpt
There is a clinical need for HIV protease inhibitors that can evade resistance mutations. One possible approach to designing such inhibitors relies upon the crystallographic observation that the substrates of HIV protease occupy a rather constant region within the binding site. In particular, it has been hypothesized that inhibitors which lie within this region will tend to resist clinically relevant mutations....
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