Evaluation of the substrate envelope hypothesis for inhibitors of HIV-1 protease.

Abstract excerpt

Crystallographic data show that various substrates of HIV protease occupy a remarkably uniform region within the binding site; this region has been termed the substrate envelope. It has been suggested that an inhibitor that fits within the substrate envelope should tend to evade viral resistance because a protease mutation that reduces the affinity of the inhibitor will also tend to reduce the affinity of...

Topics

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• Crystallography, X-Ray
• HIV-1
• HIV Protease
• HIV Protease Inhibitors
• Kinetics