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Article

Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Dec 2009

Karppinen Jaro, Solovieva Svetlana, Luoma Katariina, Raininko Raili, Leino-Arjas Päivi, Riihimäki Hilkka

Abstract excerpt

According to recent systematic reviews, Modic changes are associated with low-back pain. However, their pathophysiology remains largely unknown. A previous study of Northern Finnish males implicated that IL1A and MMP3 polymorphisms play a role in type II Modic changes. The purpose of the current...

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Identifiers

PMID: 19701653
DOI: 10.1007/s00586-009-1139-x
PMCID: PMC2899448

Genes

MMP3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19701653-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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