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Article

Genetic factors are associated with modic changes in endplates of lumbar vertebral bodies.

Spine - 15 May 2008

Karppinen Jaro, Daavittila Iita, Solovieva Svetlana, Kuisma Mari, Taimela Simo, Natri Antero, Haapea Marianne, Korpelainen Raija, Niinimäki Jaakko, Tervonen Osmo, Ala-Kokko Leena, Männikkö Minna

Abstract excerpt

STUDY DESIGN: A cross-sectional genotype-phenotype evaluation. OBJECTIVE: To evaluate the genetic background to Modic changes in an occupational cohort. SUMMARY OF BACKGROUND DATA: Modic changes are vertebral endplate changes visible in magnetic resonance imaging. Twin studies suggest that intervertebral disc degeneration may be primarily explained by genetic factors, but no data exist on genetic factors of Modic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 18469698
DOI: 10.1097/BRS.0b013e318170fd0e

Genes

MMP3
VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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