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Article

Interleukin 1 polymorphisms and intervertebral disc degeneration.

Epidemiology (Cambridge, Mass.) - 1 Sept 2004

Solovieva Svetlana, Kouhia Sanna, Leino-Arjas Päivi, Ala-Kokko Leena, Luoma Katariina, Raininko Raili, Saarela Janna, Riihimäki Hilkka

Abstract excerpt

BACKGROUND: Enzymatic breakdown of the extracellular matrix, and possibly local inflammation, contributes to intervertebral disc degeneration. We investigated whether polymorphisms within the IL-1 gene locus are associated with lumbar disc degeneration and whether the effect of occupational physical load on disc degeneration is modified by the polymorphisms. METHODS: Genotypes were determined from 133 middle-aged...

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Source

Identifiers

PMID: 15308963
DOI: 10.1097/01.ede.0000135179.04563.35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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