Article
Extent and distribution of linkage disequilibrium in the Old Order Amish.
Genetic epidemiology - 1 Feb 2010
Van Hout Cristopher V, Levin Albert M, Rampersaud Evadnie, Shen Haiqing, O'Connell Jeffrey R, Mitchell Braxton D, Shuldiner Alan R, Douglas Julie A
Abstract excerpt
Knowledge of the extent and distribution of linkage disequilibrium (LD) is critical to the design and interpretation of gene mapping studies. Because the demographic history of each population varies and is often not accurately known, it is necessary to empirically evaluate LD on a population-specific basis. Here we present the first genome-wide survey of LD in the Old Order Amish (OOA) of Lancaster County...
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