Article
Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants.
British journal of clinical pharmacology - 1 Aug 2009
Kwadijk-de Gijsel Sonja, Bijl Monique J, Visser Loes E, van Schaik Ron H N, Hofman Albert, Vulto Arnold G, van Gelder Teun, Ch Stricker Bruno H
Abstract excerpt
AIM: To study the effect of the CYP2D6*4 polymorphism on serum sodium concentration in users of antidepressants [selective serotonin reuptake inhibitors and tricyclic antidepressants (TCAs)]. METHODS: In this population-based cohort study, all subjects in the Rotterdam Study were included who used an antidepressant at baseline and from whom a blood sample was available in which CYP2D6 genotype and serum sodium...
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