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Article

Ecstasy (MDMA)-induced hyponatraemia is associated with genetic variants in CYP2D6 and COMT.

Journal of psychopharmacology (Oxford, England) - 1 Mar 2012

Aitchison Katherine J, Tsapakis Evangelia M, Huezo-Diaz Patricia, Kerwin Robert W, Forsling Mary L, Wolff Kim

Abstract excerpt

We hypothesised that genetically determined poor metabolism of 3,4-methylene dioxymetamphetamine (MDMA) due either to the presence of CYP2D6 genotypes giving absent or low CYP2D6 enzyme activity, or a COMT genotype predicting low COMT enzyme activity would be associated with a greater degree of MDMA-induced reduction in plasma sodium and osmolality than other genotypes at these genes following consumption of...

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Identifiers

PMID: 22303032
DOI: 10.1177/0269881111434624

Genes

COMT
AVP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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