Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two distinct cDNAs for human IMP dehydrogenase.

1 Mar 1990

Abstract excerpt

IMP dehydrogenase (EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis, is a promising target in antileukemic chemotherapy. We have isolated two distinct cDNA clones (types I and II) encoding IMP dehydrogenase from a human spleen cDNA library. Both clones encode closely related proteins of 514 residues showing 84% sequence identity. Northern hybridization analyses of poly(A)+ RNA from human normal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Adenosine and Purinergic Signaling
Share to Biochemical and Molecular Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1969416
DOI: 10.1016/s0021-9258(19)34120-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Two distinct cDNAs for human IMP dehydrogenase.PMID 1969416Read ↗

Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase.Semantic proximity Read ↗

IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA.Semantic proximity Read ↗

The RNA-binding Protein IMP-3 Is a Translational Activator of Insulin-like Growth Factor II Leader-3 mRNA during Proliferation of Human K562 Leukemia CellsSemantic proximity Read ↗

Structures of human genes coding for cytokine LD78 and their expression.Semantic proximity Read ↗

Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons.Semantic proximity Read ↗

Application for PCR technology to subtractive cDNA cloning: identification of genes expressed specifically in murine plasmacytoma cells.Semantic proximity Read ↗

Cloning and sequence of a cDNA encoding human carbamyl phosphate synthetase I: molecular analysis of hyperammonemia.Semantic proximity Read ↗

Nucleotide sequence of murine purine nucleoside phosphorylase cDNA.Semantic proximity Read ↗

Amplification and molecular cloning of the IMP dehydrogenase gene of Leishmania donovaniSemantic proximity Read ↗

Structural and functional characterization of the mouse multidrug resistance gene family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.